Sorry I personally can't give you a quick yes or no here. I've been out of the MicroSoft tech silo for a few years and am just about to hop back in and explore a bit now that PureMVC gives me a gateway to get there with a methodology I understand.
Anyhow, if this were posted under the 'Port to C#' board it would capture the attention of the C# port owner, Andy, who could give you a succint answer.
I would move the thread to that board but I'm on a phone right now and I don't have that option.
I can tell you that .NET 3.5 and WPF are supported if this helps at all.
For now, I suggest reposting to the C# Port board or going to the C# port and contacting the Port owner directly. The port is at http://trac.puremvc.org/PureMVC_CSharp